An extract from the African oyster mushroom (Pleurotus ostreatus) showed powerful sedative and anti-seizure effects in mice. It reduced how long it took the mice to fall asleep, extended sleep duration, and offered strong protection against chemically induced seizures. Even at high doses (up to 3200 mg/kg), the extract showed no signs of toxicity, making it a promising, natural candidate for managing epilepsy and anxiety without the harsh side effects of conventional drugs.