User reports combining psilocybin or LSD with serotonergic antidepressants showed mostly reduced psychedelic effects, with 65% reporting blunting. Even so, meaningful or therapeutic experiences still appeared in 22% of cases. Signs of serotonin toxicity showed up only with LSD in 10 percent of reports and not with psilocybin, suggesting a potentially safer profile for psilocybin. Lack of clear guidance also led to risky behaviors, including extreme dose increases in 22% of users and sudden antidepressant discontinuation in 17%