Mood & Mental Health

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Study

Blood Gene Test May Predict Who Responds to Psilocybin for Anxiety

Blood Gene Test May Predict Who Responds to Psilocybin for Anxiety

Psilocybin mushrooms

What they found

Psilocybin therapy for generalized anxiety had a 44% response rate, and a 4-gene blood panel helped separate responders.

Psilocybin therapy for generalized anxiety had a 44% response rate, and a 4-gene blood panel helped separate responders.

The number

44% response rate and 27% remission at 11 weeks

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Psilocybe spp.

Psilocybe spp.

Compound

psilocybin

psilocybin

Published in

International Journal of Neuropsychopharmacology

International Journal of Neuropsychopharmacology

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Predicting Psilocybin Response

Predicting Psilocybin Response

Psilocybin mushrooms (Psilocybe spp.) assisted therapy for generalized anxiety disorder showed a 44% response rate and 27% remission at 11 weeks. A blood-based, multi-omic analysis flagged a 4-gene expression panel (CTXN2-AS1, DUT-AS1, HLA-V, PARP16) that separated 45% of responders from non-responders—an early step toward tests that could match patients to treatment.

Psilocybin mushrooms (Psilocybe spp.) assisted therapy for generalized anxiety disorder showed a 44% response rate and 27% remission at 11 weeks. A blood-based, multi-omic analysis flagged a 4-gene expression panel (CTXN2-AS1, DUT-AS1, HLA-V, PARP16) that separated 45% of responders from non-responders—an early step toward tests that could match patients to treatment.

Psilocybin’s Edge, Space-Built Mycelium, and a Radiation Shield from Mushrooms

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