Researchers at Washington University scanned participants' brains before and after administering psilocybin, revealing a "wild neural storm" with significant brain activity changes, especially in areas involved in introspection and self-identity. Dr. Joshua Siegel explained, “The activity in these networks became much more disorganized, and boundaries between the networks essentially evaporated.” This desynchronization aligns with increased brain plasticity, potentially explaining why psilocybin can help with conditions like depression and addiction.