Supplement Quality

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Study

CO₂-extracted Reishi Oil Strongly Cut Inflammation in Lab Tests

CO₂-extracted Reishi Oil Strongly Cut Inflammation in Lab Tests

Reishi, Lion's mane, Snow fungus

What they found

CO₂-extracted reishi oil cut the inflammatory marker IL-6 by 80–90% and was the strongest of three mushrooms tested.

CO₂-extracted reishi oil cut the inflammatory marker IL-6 by 80–90% and was the strongest of three mushrooms tested.

The number

cutting IL-6 levels by 80-90%

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Ganoderma lucidum, Hericium erinaceus, Tremella fuciformis

Ganoderma lucidum, Hericium erinaceus, Tremella fuciformis

Compound

linoleic acid; triterpenoids

linoleic acid; triterpenoids

Published in

Food Research International (Ottawa, Ont.)

Food Research International (Ottawa, Ont.)

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Green Extraction Gains

Green Extraction Gains

A CO₂-based eco extraction of reishi (Ganoderma lucidum), lion’s mane (Hericium erinaceus), and snow fungus (Tremella fuciformis) produced highly potent anti-inflammatory and antioxidant oils. Reishi came out strongest, cutting IL-6 levels by 80-90% and showing powerful antioxidant activity with an IC₅₀ of 258.9 μg/mL. The benefits were tied to fatty compounds like linoleic acid and triterpenoids, and while alcohol extraction increased yield, it weakened the anti-inflammatory effects.

A CO₂-based eco extraction of reishi (Ganoderma lucidum), lion’s mane (Hericium erinaceus), and snow fungus (Tremella fuciformis) produced highly potent anti-inflammatory and antioxidant oils. Reishi came out strongest, cutting IL-6 levels by 80-90% and showing powerful antioxidant activity with an IC₅₀ of 258.9 μg/mL. The benefits were tied to fatty compounds like linoleic acid and triterpenoids, and while alcohol extraction increased yield, it weakened the anti-inflammatory effects.

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