Chaga (Inonotus obliquus) contains at least 26 active compounds, including quercetin, epigallocatechin gallate, and kaempferol, that were mapped against over 5,000 colorectal cancer genes. Network analysis pinpointed nine core targets linked to tumor growth and survival. Docking studies showed strong binding (–7 to –10 kcal/mol) of chaga compounds to these proteins. Together, the findings suggest Chaga’s phytochemicals could influence multiple cancer-related pathways, though lab and clinical validation are still needed.