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CRISPR-edited Cordyceps Makes More Beta-Glucans

CRISPR-edited Cordyceps Makes More Beta-Glucans

Cordyceps

What they found

CRISPR insertion of a glucan synthase gene made cordyceps grow faster and produce more beta-glucans.

CRISPR insertion of a glucan synthase gene made cordyceps grow faster and produce more beta-glucans.

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Cordyceps militaris

Cordyceps militaris

Compound

β-glucans

β-glucans

Published in

Journal of Agricultural and Food Chemistry

Journal of Agricultural and Food Chemistry

Covered in Shroom Scan

Section

GROWING & GOURMET

GROWING & GOURMET

As it ran in Shroom Scan

CRISPR Boosts Cordyceps

CRISPR Boosts Cordyceps

For the first time, scientists used CRISPR-Cas9 to precisely insert a large glucan synthase gene into cordyceps (Cordyceps militaris), enhancing its ability to produce β-glucans, key compounds for immune support. The edited strain grew faster, showed stronger resistance to stress, and produced more high-quality polysaccharides. This breakthrough sets the stage for safer, more efficient mushroom biotech aimed at immunity and longevity.

For the first time, scientists used CRISPR-Cas9 to precisely insert a large glucan synthase gene into cordyceps (Cordyceps militaris), enhancing its ability to produce β-glucans, key compounds for immune support. The edited strain grew faster, showed stronger resistance to stress, and produced more high-quality polysaccharides. This breakthrough sets the stage for safer, more efficient mushroom biotech aimed at immunity and longevity.

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