Safety & Toxicity

·

Study

Diabetes Drug Protected Mice From Death Cap Poisoning

Diabetes Drug Protected Mice From Death Cap Poisoning

Death cap

What they found

Rosiglitazone at 20 mg/kg protected mice from death cap toxin α-amanitin, cutting liver enzymes by more than 50%.

Rosiglitazone at 20 mg/kg protected mice from death cap toxin α-amanitin, cutting liver enzymes by more than 50%.

The number

>50%

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Amanita phalloides

Amanita phalloides

Compound

α-amanitin; rosiglitazone

α-amanitin; rosiglitazone

Published in

Journal of Biochemical and Molecular Toxicology

Journal of Biochemical and Molecular Toxicology

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Death Cap Toxin Shield

Death Cap Toxin Shield

The diabetes drug rosiglitazone (a PPAR-γ activator) at 20 mg/kg protected mice from α-amanitin, the lethal toxin in death cap mushrooms (Amanita phalloides), cutting liver enzymes ALT and AST by >50%, lowering oxidative damage, and restoring antioxidant defenses. The result was sharply reduced liver failure and improved survival after exposure to one of the deadliest mushroom poisons.

The diabetes drug rosiglitazone (a PPAR-γ activator) at 20 mg/kg protected mice from α-amanitin, the lethal toxin in death cap mushrooms (Amanita phalloides), cutting liver enzymes ALT and AST by >50%, lowering oxidative damage, and restoring antioxidant defenses. The result was sharply reduced liver failure and improved survival after exposure to one of the deadliest mushroom poisons.

Cholesterol Flush, Death Cap Antidote, and Eating-Disorder Trials

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