New research shows that dementia cases in the U.S. are set to double by 2060, with a 42% lifetime risk after age 55. Eating mushrooms twice a week cuts mild cognitive impairment risk by 50%. Lion’s mane stimulates brain repair, while reishi reduces Alzheimer’s-linked plaques. Even novel fungi, like Daldinia eschscholtzii and Thelephora aurantiotincta, outperform pharmaceuticals against neurodegeneration. Medicinal mushrooms’ integration into preventive care is an imperative we can no longer afford to ignore.