A major narrative review shows that regularly eating whole mushrooms—fresh or dried—can lower triglycerides, support healthy blood pressure, reduce fasting glucose when part of a broader healthy diet, and may boost immune markers like salivary IgA. Across 22 human studies, mushrooms consistently showed no negative effects on cholesterol, inflammation markers, or other cardiometabolic risks, and in several cases delivered modest, but meaningful improvements. Because Americans typically eat only about 4 grams per day, far below the 13–300 grams used in research, the review suggests that simply eating more mushrooms could offer a practical dietary strategy for better metabolic and immune health.