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Study

Engineered E. coli Makes Psilocybin 17 Times More Efficiently

Engineered E. coli Makes Psilocybin 17 Times More Efficiently

Psilocybin mushrooms

What they found

Modified E. coli produced psilocybin from scratch at 79.4 mg/L, a 17-fold gain over earlier microbial methods.

Modified E. coli produced psilocybin from scratch at 79.4 mg/L, a 17-fold gain over earlier microbial methods.

The number

79.4 mg/L—a 17-fold increase

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Microbial Biotechnology

Microbial Biotechnology

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Engineered Psilocybin Boost

Engineered Psilocybin Boost

Scientists successfully modified E. coli to produce psilocybin from scratch, hitting a yield of 79.4 mg/L—a 17-fold increase over previous microbial methods. They created a biosynthetic pathway that works without feeding in any psilocybin precursors and this breakthrough could make clinical-grade psilocybin far more affordable and accessible.

Scientists successfully modified E. coli to produce psilocybin from scratch, hitting a yield of 79.4 mg/L—a 17-fold increase over previous microbial methods. They created a biosynthetic pathway that works without feeding in any psilocybin precursors and this breakthrough could make clinical-grade psilocybin far more affordable and accessible.

Faster Thinking, Safer Cordyceps, and a Psilocybin Milestone

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