Female hormones like estrogen and progesterone directly influence how psychedelics such as psilocybin work in the body. Estrogen boosts serotonin activity and receptor density, which can heighten the intensity of a trip during high-estrogen phases, while progesterone may dampen effects through calming GABA pathways. Women often report more emotionally intense experiences, with stronger breakthroughs and catharsis, compared to men. The review also highlights potential benefits for menopausal health, where psychedelics may ease mood swings, depression, and brain fog by supporting neuroplasticity and serotonin balance.