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First Trial of Psilocybin Therapy for Autistic Adults With Depression

First Trial of Psilocybin Therapy for Autistic Adults With Depression

Psilocybin mushrooms

What they found

A trial will give 20 autistic adults with treatment-resistant depression 10 mg and 25 mg psilocybin doses with therapy.

A trial will give 20 autistic adults with treatment-resistant depression 10 mg and 25 mg psilocybin doses with therapy.

The number

Twenty participants

How solid is it?

n/a

n/a

Not a study

Not a study

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

Twenty participants

Twenty participants

Published in

www.autismontario.com

www.autismontario.com

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Helping Autistic Adults

Helping Autistic Adults

A first-of-its-kind clinical trial is testing psilocybin-assisted therapy (PAT) for autistic adults with treatment-resistant depression (TRD). Twenty participants will receive two doses—10mg and 25mg—alongside therapy, with brain imaging tracking changes in connectivity and mood. Previous research in neurotypical people with TRD showed 67% remission after one week and 58% maintaining significant improvement at three months.

A first-of-its-kind clinical trial is testing psilocybin-assisted therapy (PAT) for autistic adults with treatment-resistant depression (TRD). Twenty participants will receive two doses—10mg and 25mg—alongside therapy, with brain imaging tracking changes in connectivity and mood. Previous research in neurotypical people with TRD showed 67% remission after one week and 58% maintaining significant improvement at three months.

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