Golden mushroom (Floccularia luteovirens) polysaccharides (200–800 mg/kg for 14 days) lowered key liver damage markers in alcohol-exposed mice while sharply reducing inflammatory signals. Treatment suppressed oxidative stress by decreasing ROS and MDA in liver tissue and boosting antioxidant enzymes that reinforce the liver’s internal repair systems. Mechanistically, the mushroom helped shut down the inflammatory cascade that drives alcohol-related liver injury.