Cancer

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Study

Gut Fungi Turn Steroid Hormones Into New Compounds

Gut Fungi Turn Steroid Hormones Into New Compounds

What they found

Intestinal fungi turned testosterone and nandrolone into 22 metabolites, one of which killed cervical cancer cells in lab tests.

Intestinal fungi turned testosterone and nandrolone into 22 metabolites, one of which killed cervical cancer cells in lab tests.

The number

22 distinct metabolites

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

testosterone; nandrolone

testosterone; nandrolone

Published in

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Gut Fungi Power

Gut Fungi Power

Intestinal fungi were able to transform steroid hormones like testosterone and nandrolone into 22 distinct metabolites, including eight new compounds. One of these showed strong cytotoxic activity against HeLa cervical cancer cells by activating the p53 tumor-suppressing pathway.

Intestinal fungi were able to transform steroid hormones like testosterone and nandrolone into 22 distinct metabolites, including eight new compounds. One of these showed strong cytotoxic activity against HeLa cervical cancer cells by activating the p53 tumor-suppressing pathway.

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