Addiction

·

Study

How People Process a Psilocybin Trip Predicted Staying Sober

How People Process a Psilocybin Trip Predicted Staying Sober

Psilocybin mushrooms

What they found

After one 25 mg psilocybin session, 55% of people with alcohol use disorder and depression were abstinent at 3 months.

After one 25 mg psilocybin session, 55% of people with alcohol use disorder and depression were abstinent at 3 months.

The number

55% abstinence at 3 months (11 of 20 participants)

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

20 participants

20 participants

Published in

ScienceDirect

ScienceDirect

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Integration Predicts Sobriety

Integration Predicts Sobriety

In people with alcohol use disorder and depression, one psilocybin session (25 mg) led to 55% abstinence at 3 months (11 of 20 participants). Those who stayed sober used more insight- and self-reflection language in integration sessions (56% inner dialogue, meaning-making, future planning), while those who relapsed showed more sensory and distress-focused language (44% tied to pain, disappointment, suppression). In short: the way people made sense of the experience afterward, not just the drug itself, strongly tracked who stayed sober.

In people with alcohol use disorder and depression, one psilocybin session (25 mg) led to 55% abstinence at 3 months (11 of 20 participants). Those who stayed sober used more insight- and self-reflection language in integration sessions (56% inner dialogue, meaning-making, future planning), while those who relapsed showed more sensory and distress-focused language (44% tied to pain, disappointment, suppression). In short: the way people made sense of the experience afterward, not just the drug itself, strongly tracked who stayed sober.

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