Mood & Mental Health

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Review

How Psilocybin Rewires the Brain to Relieve Depression

How Psilocybin Rewires the Brain to Relieve Depression

Psilocybin mushrooms

What they found

A review links psilocybin's effects on serotonin and neuroplasticity to lasting relief from treatment-resistant depression.

A review links psilocybin's effects on serotonin and neuroplasticity to lasting relief from treatment-resistant depression.

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Expert Review of Clinical Pharmacology

Expert Review of Clinical Pharmacology

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Rewiring for Depression

Rewiring for Depression

This comprehensive review unpacks how psychedelics like psilocybin relieve depression by rewiring the brain's serotonin systems, enhancing neuroplasticity, and promoting emotional breakthroughs through altered states of consciousness. The paper connects molecular effects to lasting shifts in meaning-making, offering clarity on why psychedelic therapy may be so effective for treatment-resistant depression.

This comprehensive review unpacks how psychedelics like psilocybin relieve depression by rewiring the brain's serotonin systems, enhancing neuroplasticity, and promoting emotional breakthroughs through altered states of consciousness. The paper connects molecular effects to lasting shifts in meaning-making, offering clarity on why psychedelic therapy may be so effective for treatment-resistant depression.

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