This therapy protocol doc for psilocybin-assisted treatment of depression standardizes doses up to 25 mg within 6–8 hour sessions, guided by two therapists and followed by integration at 1 day, 1 week, and up to 12 months. It defines everything from therapist roles to room setup, including eyeshades, continuous monitoring, and tightly controlled “set and setting” to shape the experience. What I found fascinating, among many other things, was that the protocol includes fully curated music playlists organized into timed blocks that guide the emotional arc of the session, positioning sound as a core driver of therapeutic outcomes.