Polysaccharides from king bolete (Boletus edulis) blocked a key inflammatory pathway (RAGE–ROS–MAPK) tied to lipotoxicity and metabolic disease. In lab-grown liver cells, they reduced fat buildup, oxidative stress, and improved glucose uptake. In high-fat diet mice, injections of the extract reversed metabolic dysfunction and inflammation, pointing to its potential as a natural therapy for metabolic syndrome.