Polysaccharides from lion’s mane (Hericium erinaceus) boosted the growth, survival, and gut-lining adhesion of beneficial probiotic bacteria in lab models, while also showing antioxidant activity. One fraction increased probiotic adhesion to intestinal cells by up to 30% and helped keep over 70% of probiotics alive after long-term cold storage, suggesting these fibers actively support how probiotics function, not just whether they’re present. The findings are in vitro, but they reinforce lion’s mane as a gut-support mushroom that may complement its better-known cognitive reputation by feeding and stabilizing beneficial microbes.