This digestion-model evidence shows that high cadmium numbers on paper do not automatically translate to real human exposure from eating mushrooms. Although button mushroom (Agaricus blazei) contained the highest total cadmium at 3.84 mg/kg, only about 5.7% became bioaccessible during simulated digestion, meaning more than 94% remained chemically bound and unabsorbable. Other commonly eaten species including shiitake (Lentinula edodes), morel (Morchella esculenta), cordyceps (Cordyceps militaris), wine cap (Stropharia rugosoannulata), and fried chicken mushroom (Lyophyllum decastes) released no detectable cadmium at all, showing that most heavy metals in mushrooms are locked in insoluble forms that pass through the body rather than entering the bloodstream.