Pain & Headache

·

Study

Low-Dose Psilocybin Tested for Rare Headache Attacks

Low-Dose Psilocybin Tested for Rare Headache Attacks

Psilocybin mushrooms

What they found

Two of three patients with SUNHA headaches had over 50% fewer daily attacks on low-dose psilocybin, but evidence was inconclusive.

Two of three patients with SUNHA headaches had over 50% fewer daily attacks on low-dose psilocybin, but evidence was inconclusive.

The number

Two out of three participants experienced over a 50% reduction in daily headache attacks

How solid is it?

Early human

Early human

Human – observational/survey

Human – observational/survey

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

3 participants

3 participants

Published in

Headache

Headache

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Headache Attacks

Headache Attacks

The effects of low-dose psilocybin on patients with short-lasting unilateral neuralgiform headache attacks (SUNHA) also was published in a study. Patients received ascending doses of psilocybin (5, 7.5, 10 mg) along with psychological support. Although no significant adverse events were reported, cognitive data was not collected as planned due to strong subjective dose intensity. Two out of three participants experienced over a 50% reduction in daily headache attacks, but the overall clinical evidence was inconclusive.

The effects of low-dose psilocybin on patients with short-lasting unilateral neuralgiform headache attacks (SUNHA) also was published in a study. Patients received ascending doses of psilocybin (5, 7.5, 10 mg) along with psychological support. Although no significant adverse events were reported, cognitive data was not collected as planned due to strong subjective dose intensity. Two out of three participants experienced over a 50% reduction in daily headache attacks, but the overall clinical evidence was inconclusive.

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