Brain & Cognition

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Study

Low Psilocybin Doses Improved Mood and Memory in Older Mice

Low Psilocybin Doses Improved Mood and Memory in Older Mice

Psilocybin mushrooms

What they found

Two low, spaced psilocybin doses reduced depressive-like behavior in older mice and reversed age-related DNA methylation.

Two low, spaced psilocybin doses reduced depressive-like behavior in older mice and reversed age-related DNA methylation.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Healthy Aging Support

Healthy Aging Support

Psilocybin improved mood and memory in older mice by actively reshaping aging brain pathways. Two low, spaced doses reduced depressive-like behavior across sexes and boosted spatial memory in females, while also reversing age-related DNA methylation patterns in key brain regions. These epigenetic shifts centered on genes involved in neuroplasticity and immune signaling, suggesting psilocybin may help the aging brain stay flexible and resilient.

Psilocybin improved mood and memory in older mice by actively reshaping aging brain pathways. Two low, spaced doses reduced depressive-like behavior across sexes and boosted spatial memory in females, while also reversing age-related DNA methylation patterns in key brain regions. These epigenetic shifts centered on genes involved in neuroplasticity and immune signaling, suggesting psilocybin may help the aging brain stay flexible and resilient.

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