Mood & Mental Health

·

Study

LSD and Psilocybin Both Helped Patients in Swiss Compassionate Use

LSD and Psilocybin Both Helped Patients in Swiss Compassionate Use

Psilocybin mushrooms

What they found

In 115 Swiss patients given LSD or psilocybin, 37% had more than a 50% drop in depressive symptoms, with no difference between drugs.

In 115 Swiss patients given LSD or psilocybin, 37% had more than a 50% drop in depressive symptoms, with no difference between drugs.

The number

37% of all participants achieving more than 50% reduction in depressive symptoms

How solid is it?

Early human

Early human

Human – observational/survey

Human – observational/survey

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

LSD, psilocybin

LSD, psilocybin

Sample size

115 patients

115 patients

Published in

Psychiatry Research

Psychiatry Research

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Real-World Mental Health Shifts

Real-World Mental Health Shifts

In a Swiss compassionate-use program, 115 patients received either 100 µg LSD (n=70) or 25 mg psilocybin (n=45), with outcomes tracked for up to 3 months. Depression and anxiety scores fell significantly over time, with 37% of all participants achieving more than 50% reduction in depressive symptoms and no meaningful difference in improvement between LSD and psilocybin groups.

In a Swiss compassionate-use program, 115 patients received either 100 µg LSD (n=70) or 25 mg psilocybin (n=45), with outcomes tracked for up to 3 months. Depression and anxiety scores fell significantly over time, with 37% of all participants achieving more than 50% reduction in depressive symptoms and no meaningful difference in improvement between LSD and psilocybin groups.

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