Maitake mushroom (Grifola frondosa) extract triggered cancer cell death at doses of ~0.004–0.01 oz per cup, with stronger effects over 24–48 hours. When combined with chemotherapy drugs like cisplatin and taxol, it significantly increased cancer cell death compared to either drug alone and further disrupted tumor structure in 3D models. This suggests it can make standard cancer treatments work more effectively, potentially allowing for lower drug doses with the same impact.