Mood & Mental Health

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Review

Meta-Analysis: Psilocybin Reduces Major Depression Symptoms

Meta-Analysis: Psilocybin Reduces Major Depression Symptoms

Psilocybin mushrooms

What they found

A meta-analysis of three trials with 389 participants found psilocybin significantly reduced major depression, strongest at day 15 with 25 mg.

A meta-analysis of three trials with 389 participants found psilocybin significantly reduced major depression, strongest at day 15 with 25 mg.

The number

three clinical trials with 389 participants

How solid is it?

Strong human

Strong human

Meta-analysis/systematic review

Meta-analysis/systematic review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

389 participants

389 participants

Published in

ScienceDirect

ScienceDirect

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Breaking Through

Breaking Through

A meta-analysis of three clinical trials with 389 participants found that psilocybin significantly reduced symptoms of Major Depressive Disorder (MDD), with the greatest effects seen at Day 15 using a 25 mg dose.

A meta-analysis of three clinical trials with 389 participants found that psilocybin significantly reduced symptoms of Major Depressive Disorder (MDD), with the greatest effects seen at Day 15 using a 25 mg dose.

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