Mood & Mental Health

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Review

Meta-Analysis: Psilocybin Therapy Triples Depression Remission Rates

Meta-Analysis: Psilocybin Therapy Triples Depression Remission Rates

Psilocybin mushrooms

What they found

Across six trials with 427 participants, psilocybin therapy tripled response and remission rates for depression.

Across six trials with 427 participants, psilocybin therapy tripled response and remission rates for depression.

The number

Response and remission rates were three times higher with psilocybin

How solid is it?

Strong human

Strong human

Meta-analysis/systematic review

Meta-analysis/systematic review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

427 participants

427 participants

Published in

Acta Psychiatrica Scandinavica

Acta Psychiatrica Scandinavica

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Reducing Depression

Reducing Depression

A meta-analysis of six trials (427 participants) found psilocybin-assisted therapy significantly reduced depression scores compared to other treatments, with effects lasting at least six weeks. Response and remission rates were three times higher with psilocybin, though mild side effects like headaches and dizziness were more common.

A meta-analysis of six trials (427 participants) found psilocybin-assisted therapy significantly reduced depression scores compared to other treatments, with effects lasting at least six weeks. Response and remission rates were three times higher with psilocybin, though mild side effects like headaches and dizziness were more common.

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