Brain & Cognition

·

Study

Morel Extract Blocks an Alzheimer's-Linked Enzyme

Morel Extract Blocks an Alzheimer's-Linked Enzyme

Morel

What they found

A green morel extract strongly inhibited acetylcholinesterase (IC50 = 0.002 mg/mL) and kept over 66% of activity after digestion.

A green morel extract strongly inhibited acetylcholinesterase (IC50 = 0.002 mg/mL) and kept over 66% of activity after digestion.

The number

IC50 = 0.002 mg/mL

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Morchella esculenta

Morchella esculenta

Compound

polyphenols, flavonoids

polyphenols, flavonoids

Published in

International Journal of Medicinal Mushrooms

International Journal of Medicinal Mushrooms

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Healthy Morels

Healthy Morels

A green extraction of morel mushrooms (Morchella esculenta) yielded high levels of polyphenols and flavonoids, with strong antioxidant and antibacterial activity. The extract showed powerful inhibition of acetylcholinesterase (IC50 = 0.002 mg/mL), a key enzyme linked to Alzheimer’s disease. After 4 hours of simulated digestion, over 66% of its neuroprotective and antioxidant activity remained.

A green extraction of morel mushrooms (Morchella esculenta) yielded high levels of polyphenols and flavonoids, with strong antioxidant and antibacterial activity. The extract showed powerful inhibition of acetylcholinesterase (IC50 = 0.002 mg/mL), a key enzyme linked to Alzheimer’s disease. After 4 hours of simulated digestion, over 66% of its neuroprotective and antioxidant activity remained.

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