Mood & Mental Health

·

Study

Non-Hallucinogenic Compound Mimics Psilocybin's Brain Plasticity

Non-Hallucinogenic Compound Mimics Psilocybin's Brain Plasticity

Psilocybin mushrooms

What they found

Tabernanthalog boosted brain plasticity via the same pathways as psilocybin without causing hallucinations.

Tabernanthalog boosted brain plasticity via the same pathways as psilocybin without causing hallucinations.

How solid is it?

Unclear

Unclear

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

tabernanthalog (TBG)

tabernanthalog (TBG)

Published in

Nature Neuroscience

Nature Neuroscience

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

No Trip, Same Benefit?

No Trip, Same Benefit?

A new compound called tabernanthalog (TBG) boosts brain plasticity like psilocybin, but without causing hallucinations. TBG activates the same key pathways (5-HT2A, TrkB, mTOR, AMPA) involved in neuron growth and mood improvement, but skips the typical “trip” effects like glutamate spikes or early gene activation.

A new compound called tabernanthalog (TBG) boosts brain plasticity like psilocybin, but without causing hallucinations. TBG activates the same key pathways (5-HT2A, TrkB, mTOR, AMPA) involved in neuron growth and mood improvement, but skips the typical “trip” effects like glutamate spikes or early gene activation.

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