Mood & Mental Health

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Study

Non-Hallucinogenic Psychedelics Show Antidepressant Effects

Non-Hallucinogenic Psychedelics Show Antidepressant Effects

Psilocybin mushrooms

What they found

A review of 17 studies found non-hallucinogenic psychedelics like lisuride and 2-Br-LSD had antidepressant effects in animals.

A review of 17 studies found non-hallucinogenic psychedelics like lisuride and 2-Br-LSD had antidepressant effects in animals.

The number

17 studies

How solid is it?

Animal

Animal

Meta-analysis/systematic review

Meta-analysis/systematic review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

lisuride, 2-Br-LSD, psilocybin

lisuride, 2-Br-LSD, psilocybin

Sample size

17 studies

17 studies

Published in

ScienceDirect

ScienceDirect

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Next-Gen Psychedelics

Next-Gen Psychedelics

This review covers 17 studies on non-hallucinogenic psychedelics for mood and anxiety disorders. Compounds like lisuride and 2-Br-LSD showed antidepressant effects in animal models without causing hallucinations. In one human case, psilocybin paired with a serotonin blocker still improved mood, suggesting the visual trip isn’t required for therapeutic benefits. It opens the door to safer, stigma-free treatments that could reach more people.

This review covers 17 studies on non-hallucinogenic psychedelics for mood and anxiety disorders. Compounds like lisuride and 2-Br-LSD showed antidepressant effects in animal models without causing hallucinations. In one human case, psilocybin paired with a serotonin blocker still improved mood, suggesting the visual trip isn’t required for therapeutic benefits. It opens the door to safer, stigma-free treatments that could reach more people.

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