Mood & Mental Health

·

Study

One Psilocybin Dose Helped Veterans With Severe Depression

One Psilocybin Dose Helped Veterans With Severe Depression

Psilocybin mushrooms

What they found

In a pilot of 15 veterans with treatment-resistant depression, one 25 mg psilocybin dose led to 53% remission at three weeks.

In a pilot of 15 veterans with treatment-resistant depression, one 25 mg psilocybin dose led to 53% remission at three weeks.

The number

60% of participants showed a significant reduction in depression symptoms, with 53% achieving remission

How solid is it?

Early human

Early human

Human – observational/survey

Human – observational/survey

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

15 U.S. military veterans

15 U.S. military veterans

Published in

Journal of Affective Disorders

Journal of Affective Disorders

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Veterans and Psilocybin

Veterans and Psilocybin

15 U.S. military veterans suffering from severe treatment-resistant depression tested a single 25 mg dose of psilocybin in a pilot study. At three weeks post-treatment, 60% of participants showed a significant reduction in depression symptoms, with 53% achieving remission. By the 12th week, 47% maintained symptom improvement, and 40% were still in remission. While generally well-tolerated, the most common side effects included mild headaches (47%) and nausea (20%).

15 U.S. military veterans suffering from severe treatment-resistant depression tested a single 25 mg dose of psilocybin in a pilot study. At three weeks post-treatment, 60% of participants showed a significant reduction in depression symptoms, with 53% achieving remission. By the 12th week, 47% maintained symptom improvement, and 40% were still in remission. While generally well-tolerated, the most common side effects included mild headaches (47%) and nausea (20%).

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