Mood & Mental Health

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Study

One Psilocybin Session Gives Veterans Depression Relief for a Year

One Psilocybin Session Gives Veterans Depression Relief for a Year

Psilocybin mushrooms

What they found

After one high-dose psilocybin session, 80% of veterans with treatment-resistant depression were responders at 6 months and 40% at 12 months.

After one high-dose psilocybin session, 80% of veterans with treatment-resistant depression were responders at 6 months and 40% at 12 months.

The number

80% of participants still met the criteria for clinical response

How solid is it?

Early human

Early human

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

ScienceDirect

ScienceDirect

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Veterans 12 Months Later

Veterans 12 Months Later

One high-dose psilocybin session helped veterans with severe treatment-resistant depression experience lasting relief for up to a year. At 6 months, 80% of participants still met the criteria for clinical response and 50% for remission; by 12 months, 40% maintained response and 30% remission. This marks the first study to show long-term outcomes of psilocybin in U.S. military veterans, a group underserved by current antidepressant options.

One high-dose psilocybin session helped veterans with severe treatment-resistant depression experience lasting relief for up to a year. At 6 months, 80% of participants still met the criteria for clinical response and 50% for remission; by 12 months, 40% maintained response and 30% remission. This marks the first study to show long-term outcomes of psilocybin in U.S. military veterans, a group underserved by current antidepressant options.

Brain Recovery, Chemical Cleanup, and 12 Months of Relief for Veterans

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