Brain & Cognition

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Study

One Psychedelic Dose Leaves Lasting Changes in Brain Cell RNA

One Psychedelic Dose Leaves Lasting Changes in Brain Cell RNA

What they found

A single psychedelic dose caused lasting RNA splicing changes in prefrontal brain cells that persisted after a month.

A single psychedelic dose caused lasting RNA splicing changes in prefrontal brain cells that persisted after a month.

How solid is it?

Unclear

Unclear

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psychedelics

psychedelics

Published in

bioRxiv

bioRxiv

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Lasting Changes

Lasting Changes

A single dose of psychedelics can cause enduring changes in the RNA splicing of brain cells in the prefrontal cortex. Even after gene expression returns to normal within a month, these alterations persist, potentially affecting neural connections and communication.

A single dose of psychedelics can cause enduring changes in the RNA splicing of brain cells in the prefrontal cortex. Even after gene expression returns to normal within a month, these alterations persist, potentially affecting neural connections and communication.

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