Law & Policy

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Study

Oregon Decriminalization Not Linked to Overdose Rise After Fentanyl Adjustment

Oregon Decriminalization Not Linked to Overdose Rise After Fentanyl Adjustment

What they found

Oregon’s Measure 110 was not linked to more overdose deaths once fentanyl’s spread was accounted for.

Oregon’s Measure 110 was not linked to more overdose deaths once fentanyl’s spread was accounted for.

The number

(-0.51, p=0.41)

How solid is it?

Early human

Early human

Human – observational/survey

Human – observational/survey

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

fentanyl

fentanyl

Published in

JAMA Network

JAMA Network

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Early Reports Are In

Early Reports Are In

A JAMA Network Open study found no significant link between Oregon's drug decriminalization (Measure 110) and increased overdose deaths when accounting for fentanyl's spread. Using matrix completion models, the crude association between decriminalization and overdose rates was positive (1.83 deaths/100,000/half-year, p<0.001), but disappeared when adjusting for fentanyl (-0.51, p=0.41). Fentanyl's rapid spread in Oregon coincided with Measure 110's 2021 implementation, explaining over 50% of interstate variation in overdose rates. This challenges previous studies that didn't fully consider fentanyl's impact when evaluating drug policy effects on overdose mortality.

A JAMA Network Open study found no significant link between Oregon's drug decriminalization (Measure 110) and increased overdose deaths when accounting for fentanyl's spread. Using matrix completion models, the crude association between decriminalization and overdose rates was positive (1.83 deaths/100,000/half-year, p<0.001), but disappeared when adjusting for fentanyl (-0.51, p=0.41). Fentanyl's rapid spread in Oregon coincided with Measure 110's 2021 implementation, explaining over 50% of interstate variation in overdose rates. This challenges previous studies that didn't fully consider fentanyl's impact when evaluating drug policy effects on overdose mortality.

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