Cancer

·

Study

Oyster Mushroom Glucans Help Chemo Fight Resistant Breast Cancer

Oyster Mushroom Glucans Help Chemo Fight Resistant Breast Cancer

Oyster mushroom

What they found

Oyster mushroom glucans with paclitaxel increased apoptosis sixfold in 3D breast cancer models.

Oyster mushroom glucans with paclitaxel increased apoptosis sixfold in 3D breast cancer models.

The number

increased apoptosis by sixfold

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Pleurotus ostreatus

Pleurotus ostreatus

Compound

6-glucans; paclitaxel

6-glucans; paclitaxel

Published in

BMC Complementary Medicine and Therapies

BMC Complementary Medicine and Therapies

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Breast Cancer Breakthrough

Breast Cancer Breakthrough

A combination of 6-glucans from Pleurotus ostreatus and Paclitaxel (PTX) shows promise in overcoming chemotherapy resistance in breast cancer. In 3D tumor models, 2.0 mg/mL of 6-glucans with 3.0 µg/mL PTX significantly reduced cancer cell growth, migration, and stem-like cell survival. This dual therapy increased apoptosis by sixfold, disrupted mitochondrial function, and lowered ATP levels in aggressive breast cancer cells. With a 16-point synergy score, this natural-polysaccharide-based approach could enhance chemotherapy effectiveness and reduce resistance.

A combination of 6-glucans from Pleurotus ostreatus and Paclitaxel (PTX) shows promise in overcoming chemotherapy resistance in breast cancer. In 3D tumor models, 2.0 mg/mL of 6-glucans with 3.0 µg/mL PTX significantly reduced cancer cell growth, migration, and stem-like cell survival. This dual therapy increased apoptosis by sixfold, disrupted mitochondrial function, and lowered ATP levels in aggressive breast cancer cells. With a 16-point synergy score, this natural-polysaccharide-based approach could enhance chemotherapy effectiveness and reduce resistance.

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