Hormones & Reproductive

·

Study

Paddy Straw Mushroom Curbs Inflammation Enzymes

Paddy Straw Mushroom Curbs Inflammation Enzymes

Paddy straw mushroom

What they found

Paddy straw mushroom reduced inflammation markers by up to 89% and its polysaccharide inhibited AKR1C3 by 96.17%.

Paddy straw mushroom reduced inflammation markers by up to 89% and its polysaccharide inhibited AKR1C3 by 96.17%.

The number

96.17% inhibition of AKR1C3

How solid is it?

Lab dish

Lab dish

In vitro (lab dish)

In vitro (lab dish)

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Volvopluteus gloiocephalus

Volvopluteus gloiocephalus

Compound

polysaccharides

polysaccharides

Published in

Food Bioscience

Food Bioscience

Covered in Shroom Scan

Section

HEALTH & WELLNESS

HEALTH & WELLNESS

As it ran in Shroom Scan

Hormone Control

Hormone Control

Paddy straw mushroom (Volvopluteus gloiocephalus) reduced inflammation markers by up to 89% and 84%, targeting key COX and LOX pathways. Its polysaccharide fraction showed 96.17% inhibition of AKR1C3, a hormone-related enzyme linked to cancer and metabolic disease, outperforming ibuprofen. It also selectively activated glucocorticoid receptors without affecting estrogen or androgen pathways, supporting safer hormone and inflammation regulation.

Paddy straw mushroom (Volvopluteus gloiocephalus) reduced inflammation markers by up to 89% and 84%, targeting key COX and LOX pathways. Its polysaccharide fraction showed 96.17% inhibition of AKR1C3, a hormone-related enzyme linked to cancer and metabolic disease, outperforming ibuprofen. It also selectively activated glucocorticoid receptors without affecting estrogen or androgen pathways, supporting safer hormone and inflammation regulation.

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