The PEARL trial introduces a psilocybin-assisted therapy model that integrates existential, attachment, and relational psychotherapy for patients with advanced cancer. The study evaluates how guided psilocybin sessions can ease end-of-life anxiety, strengthen emotional connection, and restore a sense of meaning and peace. By combining psychedelic support with trauma-informed therapy, the PEARL approach aims to improve quality of life and emotional well-being in palliative care.