Pain & Headache

·

Review

People Use Psilocybin to Self-Treat Cluster Headaches

People Use Psilocybin to Self-Treat Cluster Headaches

Psilocybin mushrooms

What they found

Surveys show about 70% of people self-treating cluster headaches with psilocybin or LSD report preventive benefit and about 40% full remission.

Surveys show about 70% of people self-treating cluster headaches with psilocybin or LSD report preventive benefit and about 40% full remission.

The number

~70% reporting preventive benefit and ~40% achieving full remission

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin, LSD

psilocybin, LSD

Sample size

cluster headache sample (n = 496)

cluster headache sample (n = 496)

Published in

Exploratory Research in Clinical and Social Pharmacy

Exploratory Research in Clinical and Social Pharmacy

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Headache Relief Gap

Headache Relief Gap

Psilocybin and LSD were the most common psychedelics people used to self-treat cluster headaches and chronic pain, with surveys showing ~70% reporting preventive benefit and ~40% achieving full remission, often after microdosed or single-use regimens. In a cluster headache sample (n = 496), psilocybin and LSD were rated as effective as or more effective than oxygen and triptans, with some users reporting relief within ~20 minutes.

Psilocybin and LSD were the most common psychedelics people used to self-treat cluster headaches and chronic pain, with surveys showing ~70% reporting preventive benefit and ~40% achieving full remission, often after microdosed or single-use regimens. In a cluster headache sample (n = 496), psilocybin and LSD were rated as effective as or more effective than oxygen and triptans, with some users reporting relief within ~20 minutes.

Psilocybin vs. Addiction, Superbug Killers, and Mushrooms That Make Fuel

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