A compound from the phoenix-tail mushroom (Pleurotus geesteranus) helped delay signs of aging in mice by activating NRF2, a key defense against cellular stress. The polysaccharide (called glucomannogalactan) reduced inflammation, improved metabolism, and cleared out senescent cells in both naturally aged and treatment-damaged mice. In lab models, it also helped protect human cells from stress, suggesting potential as a low-risk, natural anti-aging supplement.