Psilocybin and 5-MeO-DMT May Aid Brain Injury Recovery

Psilocybin mushrooms

What they found

Psilocybin and 5-MeO-DMT may help traumatic brain injury by boosting neuroplasticity and reducing inflammation.

How solid is it?

Review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin, 5-MeO-DMT

Published in

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Covered in Shroom Scan

Jul 18, 2025

Section

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Healing Companions

Psilocybin and 5-MeO-DMT show promise in treating traumatic brain injury by enhancing neuroplasticity and reducing inflammation. Psilocybin activates TrkB receptors for brain growth, while 5-MeO-DMT targets sigma-1 receptors for neuroprotection. Both work through serotonin pathways and could support recovery from long-term brain damage.

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