Mood & Mental Health

·

Review

Psilocybin and Ketamine Share Brain-Rewiring Pathways

Psilocybin and Ketamine Share Brain-Rewiring Pathways

Psilocybin mushrooms

What they found

Psilocybin and ketamine both boost neuroplasticity, but psilocybin also shifts emotional processing for longer-lasting effects.

Psilocybin and ketamine both boost neuroplasticity, but psilocybin also shifts emotional processing for longer-lasting effects.

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin, ketamine

psilocybin, ketamine

Published in

Molecular Psychiatry

Molecular Psychiatry

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Rewiring Pathways

Rewiring Pathways

Psilocybin and ketamine both enhance neuroplasticity through shared pathways like mTOR and BDNF/TrkB signaling, rapidly improving mood and promoting brain rewiring. But unlike ketamine, psilocybin also shifts emotional processing, reducing negative bias and supporting relearning, which may lead to longer-lasting effects.

Psilocybin and ketamine both enhance neuroplasticity through shared pathways like mTOR and BDNF/TrkB signaling, rapidly improving mood and promoting brain rewiring. But unlike ketamine, psilocybin also shifts emotional processing, reducing negative bias and supporting relearning, which may lead to longer-lasting effects.

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