Mood & Mental Health

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Review

Psilocybin and MDMA Therapy Reduce Suicidal Thoughts

Psilocybin and MDMA Therapy Reduce Suicidal Thoughts

Psilocybin mushrooms

What they found

A review of studies through November 2024 found psilocybin and MDMA therapies significantly reduced suicidal ideation in randomized trials.

A review of studies through November 2024 found psilocybin and MDMA therapies significantly reduced suicidal ideation in randomized trials.

How solid is it?

Strong human

Strong human

Meta-analysis/systematic review

Meta-analysis/systematic review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin; MDMA; LSD

psilocybin; MDMA; LSD

Published in

Journal of Clinical Medicine

Journal of Clinical Medicine

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Psychedelic Impact

Psychedelic Impact

A comprehensive review up to November 2024 examines the impact of psychedelic therapies on suicide-related outcomes. The study reveals that psilocybin and MDMA-assisted therapies significantly reduce suicidal ideation, according to randomized trials. However, results vary with LSD, where some non-randomized studies suggest an increase in suicide risk. These results underscore the importance of precise dosing and careful application in psychedelic mental health treatments.

A comprehensive review up to November 2024 examines the impact of psychedelic therapies on suicide-related outcomes. The study reveals that psilocybin and MDMA-assisted therapies significantly reduce suicidal ideation, according to randomized trials. However, results vary with LSD, where some non-randomized studies suggest an increase in suicide risk. These results underscore the importance of precise dosing and careful application in psychedelic mental health treatments.

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