A comprehensive review looked at reported experiences of psilocybin among people with bipolar disorder. Some individuals described mood relief, emotional processing, or reduced negative rumination — but others experienced mood destabilization, including hypomania or mania, particularly when doses were high, settings were unstructured, or other substances were involved. Because current evidence is based on self-reported and observational data, not controlled trials, psilocybin is not an established or clinically recommended treatment for bipolar disorder at this time.