Safety & Toxicity

·

Study

Psilocybin Caused Only Mild, Brief Heart Rate Changes in Therapy

Psilocybin Caused Only Mild, Brief Heart Rate Changes in Therapy

Psilocybin mushrooms

What they found

In supervised therapy, psilocybin caused only mild, temporary heart-rate changes and no serious cardiovascular events.

In supervised therapy, psilocybin caused only mild, temporary heart-rate changes and no serious cardiovascular events.

How solid is it?

Early human

Early human

Human – observational/survey

Human – observational/survey

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin; LSD

psilocybin; LSD

Published in

Psychology International

Psychology International

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Heart Rate Clarity

Heart Rate Clarity

In clinical psychedelic therapy settings, psilocybin caused only mild, temporary changes in heart rate that stayed well within safe ranges under medical supervision. This real-world analysis of patients treated for depression and anxiety found no serious cardiovascular events and showed that psilocybin’s heart-rate effects were brief and declined earlier than LSD’s, helping clarify cardiovascular safety expectations during supervised psychedelic care.

In clinical psychedelic therapy settings, psilocybin caused only mild, temporary changes in heart rate that stayed well within safe ranges under medical supervision. This real-world analysis of patients treated for depression and anxiety found no serious cardiovascular events and showed that psilocybin’s heart-rate effects were brief and declined earlier than LSD’s, helping clarify cardiovascular safety expectations during supervised psychedelic care.

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