Mood & Mental Health

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Study

Psilocybin Causes Short-Lived Anxiety Behavior in Rodents

Psilocybin Causes Short-Lived Anxiety Behavior in Rodents

Psilocybin mushrooms

What they found

Psilocybin caused anxiety-like behavior in rodents within 30 minutes that disappeared by 24 hours, with sex differences for norbaeocystin.

Psilocybin caused anxiety-like behavior in rodents within 30 minutes that disappeared by 24 hours, with sex differences for norbaeocystin.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin, norbaeocystin

psilocybin, norbaeocystin

Published in

digitalcommons.onu.edu

digitalcommons.onu.edu

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Short-Term Anxiety Spike

Short-Term Anxiety Spike

Psilocybin (1 mg/kg) reduced open-arm time and center exploration, while sharply decreasing movement within 30 minutes of dosing. Effects differed by sex, with norbaeocystin increasing exploratory behavior in females but reducing it in males, showing distinct biological responses. These changes disappeared by 24 hours (p = 0.93), indicating the anxiety effect is immediate but short-lived.

Psilocybin (1 mg/kg) reduced open-arm time and center exploration, while sharply decreasing movement within 30 minutes of dosing. Effects differed by sex, with norbaeocystin increasing exploratory behavior in females but reducing it in males, showing distinct biological responses. These changes disappeared by 24 hours (p = 0.93), indicating the anxiety effect is immediate but short-lived.

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