Mood & Mental Health

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Review

Psilocybin Eased Death Anxiety in Terminal Patients

Psilocybin Eased Death Anxiety in Terminal Patients

Psilocybin mushrooms

What they found

A review found psilocybin reduced death anxiety in terminal patients with benefits lasting up to 6 months after one dose.

A review found psilocybin reduced death anxiety in terminal patients with benefits lasting up to 6 months after one dose.

The number

benefits lasting up to 6 months after a single dose

How solid is it?

Review

Review

Narrative review

Narrative review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

Progress in Palliative Care

Progress in Palliative Care

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

End-of-Life Anxiety Drop

End-of-Life Anxiety Drop

Psilocybin reduced death anxiety in terminal patients with effect sizes ranging from −0.70 to −1.08, with benefits lasting up to 6 months after a single dose. It works by activating 5-HT2A receptors and disrupting rigid brain networks tied to fear and self-focus, allowing shifts in perception and meaning.

Psilocybin reduced death anxiety in terminal patients with effect sizes ranging from −0.70 to −1.08, with benefits lasting up to 6 months after a single dose. It works by activating 5-HT2A receptors and disrupting rigid brain networks tied to fear and self-focus, allowing shifts in perception and meaning.

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