Mood & Mental Health

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Study

Psilocybin Gives Large, Fast Depression Relief Across 6 Trials

Psilocybin Gives Large, Fast Depression Relief Across 6 Trials

Psilocybin mushrooms

What they found

Across 6 randomized trials, standard psilocybin doses made patients 3.38× more likely to reach remission within 2–3 weeks.

Across 6 randomized trials, standard psilocybin doses made patients 3.38× more likely to reach remission within 2–3 weeks.

The number

3.38× more likely to reach remission

How solid is it?

Strong human

Strong human

Meta-analysis/systematic review

Meta-analysis/systematic review

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Sample size

6 randomized trials

6 randomized trials

Published in

ScienceDirect

ScienceDirect

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Depression Symptom Drop

Depression Symptom Drop

Psilocybin therapy at standard doses (20–30 mg/70 kg) reduced depression severity with a large effect size (SMD: −1.05, p = 0.0002) across 6 randomized trials. Patients were 2.34× more likely to respond and 3.38× more likely to reach remission within 2–3 weeks, with benefits sustained up to 6–12 weeks. This delivers rapid, lasting symptom relief with fewer dropouts than controls, unlike traditional antidepressants that require daily dosing.

Psilocybin therapy at standard doses (20–30 mg/70 kg) reduced depression severity with a large effect size (SMD: −1.05, p = 0.0002) across 6 randomized trials. Patients were 2.34× more likely to respond and 3.38× more likely to reach remission within 2–3 weeks, with benefits sustained up to 6–12 weeks. This delivers rapid, lasting symptom relief with fewer dropouts than controls, unlike traditional antidepressants that require daily dosing.

Faster Depression Relief, Better Cholesterol, and Asthma Relief

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