Mood & Mental Health

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Study

Psilocybin Helps Stressed Mice Unlearn Fear Responses

Psilocybin Helps Stressed Mice Unlearn Fear Responses

Psilocybin mushrooms

What they found

Psilocybin reduced freezing during fear recall and improved extinction learning in mice under naïve, acute and chronic stress.

Psilocybin reduced freezing during fear recall and improved extinction learning in mice under naïve, acute and chronic stress.

How solid is it?

Animal

Animal

Animal

Animal

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin

psilocybin

Published in

ACS Pharmacology & Translational Science

ACS Pharmacology & Translational Science

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Fear Unlearned

Fear Unlearned

Psilocybin helped mice unlearn conditioned fear responses across all stress states —naïve, acute, and chronic. It reduced freezing behavior during fear recall and improved extinction learning, even when stress normally impaired flexibility.

Psilocybin helped mice unlearn conditioned fear responses across all stress states —naïve, acute, and chronic. It reduced freezing behavior during fear recall and improved extinction learning, even when stress normally impaired flexibility.

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