A new study from Johns Hopkins University investigates how psilocybin affects body weight, composition, and metabolism in mice, revealing possible applications for treating obesity and anorexia nervosa. The results: Psilocybin led to increased body weight in mice, mostly due to gains in lean mass and water content, not fat, meaning it could help build muscle mass effectively. Receptor independence : The weight gain from psilocybin did not rely on the usual brain receptors linked to mood and hunger, pointing to unique ways it may affect body weight. Metabolic insights : Elevated levels of enzymes like creatine kinase and aspartate aminotransferase in treated mice suggest that psilocybin might influence muscle and liver functions, which are crucial for overall health. Read more.