Mood & Mental Health

·

Study

Psilocybin Makes Brain Networks More Flexible Than Escitalopram

Psilocybin Makes Brain Networks More Flexible Than Escitalopram

Psilocybin mushrooms

What they found

Compared with escitalopram, psilocybin increased brain network flexibility in depression, especially in responders.

Compared with escitalopram, psilocybin increased brain network flexibility in depression, especially in responders.

How solid is it?

Early human

Early human

Human – comparative trial

Human – comparative trial

Evidence ladder: Lab dish → Animal → Early human → Strong human. Reviews summarize earlier research.

At a glance

Latin name

Compound

psilocybin; escitalopram

psilocybin; escitalopram

Published in

bioRxiv

bioRxiv

Covered in Shroom Scan

Section

PSILOCYBIN & LEGISLATION

PSILOCYBIN & LEGISLATION

As it ran in Shroom Scan

Psilocybin vs. Antidepressants

Psilocybin vs. Antidepressants

A study comparing psilocybin and escitalopram (an SSRI) for depression found that psilocybin increased brain network flexibility, especially in higher-order cognitive and attentional networks. Psilocybin responders showed greater connectivity changes than those on escitalopram, suggesting it reshapes brain function more dynamically.

A study comparing psilocybin and escitalopram (an SSRI) for depression found that psilocybin increased brain network flexibility, especially in higher-order cognitive and attentional networks. Psilocybin responders showed greater connectivity changes than those on escitalopram, suggesting it reshapes brain function more dynamically.

Flu Defense, Joint Health, and Psilocybin’s Metabolic Edge

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